CHEM 351—Biochemistry I—Fall 2026
Course Introduction
08/24
Course Syllabus
What is Biochemistry?
08/26
Arthur Kornberg (1987) "The Two Cultures: Chemistry and Biology"
Norman Pace (2001) "The universal nature of biochemistry"
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Start: 24:15
End: 33:30
Length: 9:15
Related Article: On Becoming a Scientist
On Becoming a Scientist
Water
08/28
Chp. 2 p. 47–58
May the Forces Be with You
08/31
Chp. 2 p. 47–58
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Start: 10:22
End: 17:59
Length: 7:37
What lava lamps and vinaigrette can teach us about cell biology
Suggested Problems—solubility
Ionization and Buffers
09/02
Suggested Problems—buffers
Good, et al. (1966) "Hydrogen Ion Buffers for Biological Research"
Titration Curve Example
Data Analysis with Spreadsheets
09/04
Suggested Problems—curve-fitting
Hyperbolic Data
Data for Analysis During Class
Spreadsheet Built in Class
No Class—Labor Day
09/07
Amino Acids
09/09
Chp. 3 p. 75–85
Suggested Problems—amino-acids
Protein Purification
09/11
Chp. 3 p. 85–96
Suggested Problems—protein-purification
Protein Composition Tool
Protein Isoelectric Point Calculator
SOD1 Sequence
Histone H1 Sequence
Protein Purification (continued)
09/14
Chp. 3 p. 85–96
Protein Purification (continued)
09/16
Chp. 3 p. 85–96
Tokuyama K, Clark EE and Dawson CR (1965) Ascorbate Oxidase: A New Method of Purification. Characterization of the Purified Enzyme
Peptide Structure
09/18
Chp. 4 p. 115–125
Peptide Structure
Protein Structure
09/21
Chp. 4 p. 125–142
Peptide Structure
Protein Structure (continued)
09/23
Chp. 4 p. 125–142
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Start: 0:55
End: 9:58
Length: 9:03
From Computational Design to a Protein That Binds
Installing and Using RasMol
RasMol v2.7.2.1.1
Protein Structure Data
Structural Classification of Proteins
Irving Geis—Biochemistry Art
Ligand Binding
09/25
Chp. 5 p. 157–174
Suggested Problems—ligand-binding
Ligand X Data
Ligand Y Data
Steady–State Enzyme Kinetics
09/28
Chp. 6 p. 198–204
Suggested Problems—steady-state-enzyme-kinetics
Enzyme X Data
Michaelis L and Menten ML (1913) Die Kinetik der Invertinwirkung. [Recent English Translation
Multiple Substrate/Reversible Inhibition Enzyme Kinetics
09/30
Chp. 6 p. 204–213
General Principles of Enzyme Catalysis
 **final lecture in Unit I
10/02
Chp. 6 p. 187–198
Enzyme Reaction Mechanisms
10/05
Chp. 6 p. 213–225
Enzyme Reaction Mechanisms (continued)
10/07
Chp. 6 p. 213–225
Enzyme Regulation
10/09
Chp. 6 p. 225–236
Thermodynamics
10/12
Chp. 13 p. 495–501
Suggested Problems—thermodynamics
Biochemical Reactions
10/14
Chp. 13 p. 501–527
No Class—Fall Recess
10/16
Glycolysis
10/19
Chp. 14 p. 533–553
Suggested Problems—glycolysis
Glycolysis (continued)
10/21
Chp. 14 p. 533–553
Glycolysis (continued)
10/23
Chp. 14 p. 533–553
Fermentation
10/26
Chp. 14 p. 553–558
Suggested Problems—fermentation
podcast icon Cheers to ALDH1B1, the versatile enzyme that breaks down alcohol and fights viruses
Gluconeogenesis
10/28
Chp. 14 p. 558–565
Regulation of Glycolysis/Gluconeogenesis
10/30
Chp. 15 p. 575–600
Citric Acid Cycle
11/02
Chp. 16
Suggested Problems—citric-acid-cycle
Citric Acid Cycle (continued)
11/04
Chp. 16
Citric Acid Cycle (continued)
11/06
Chp. 16
Electron Transport Chain
11/09
Chp. 19 p. 711–728
ATP Synthesis
 **final lecture in Unit II
11/11
Chp. 19 p. 728–741
Suggested Problems—atp-synthesis
Photophosphorylation
11/13
Chp. 20 p. 755–774
Suggested Problems—photophosphorylation
Photophosphorylation (continued)
11/16
Chp. 20 p. 755–774
Carbohydrate Biosynthesis
11/18
Chp. 20 p. 780–798
Suggested Problems—carbohydrate-biosynthesis
Carbohydrate Biosynthesis (continued)
11/20
Chp. 20 p. 755–774
Bar-Even, et al. (2011) "The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters"
No Class—Thanksgiving Recess
11/23
No Class—Thanksgiving Recess
11/25
No Class—Thanksgiving Recess
11/27
Urea Cycle
11/30
Chp. 18 p. 675–690
Suggested Problems—urea-cycle
Amino Acid Degradation Pathways
12/02
Chp. 18 p. 690–705
Amino Acid Degradation Pathways (continued)
12/04
Chp. 18 p. 690–705
Amino Acid Biosynthesis
12/07
Chp. 22 p. 859–880
Amino Acid Biosynthesis (continued)
12/09
Chp. 22 p. 859–880
Final Exam—13:00
12/12
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