CHEM 351—Biochemistry I—Fall 2026
Thermodynamics
[1] Calculation of ΔG ′0 from an Equilibrium Constant
Lehninger chapter 13, page 527, question 2
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See answer in Lehninger on page AS–14.
[2] Calculation of the Equilibrium Constant from ΔG ′0
Lehninger chapter 13, page 527, question 3
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See answer in Lehninger on page AS–14.
[3] Experimental Determination of K ′eq and ΔG ′0
Lehninger chapter 13, page 527, question 4
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See answer in Lehninger on page AS–14.
[4] Experimental Determination of ΔG ′0 for ATP Hydrolysis
Lehninger chapter 13, page 527, question 5
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See answer in Lehninger on page AS–14.
[5] Difference between ΔG ′0 and ΔG
Lehninger chapter 13, page 527, question 6
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See answer in Lehninger on page AS–14.
[6] The ΔG ′0 for Coupled Reactions
Lehninger chapter 13, page 528, question 9
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See answer in Lehninger on page AS–14.
[7] Effect of [ATP]/[ADP] Ratio of Free Energy of Hydrolysis of ATP
Lehninger chapter 13, page 528, question 10
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See answer in Lehninger on page AS–14.
Note that the mass-action ratio, Q, is always calculated using the molar concentrations of reactants and products.
[8] Strategy for Overcoming an Unfavorable Reaction: ATP-Dependent Chemical Coupling
Lehninger chapter 13, page 528, question 11
Note that in part (a), while the problem is written about physiological conditions in the rat hepatocyte, the authors make the calculation of the equilibrium constant at 25 oC. May your rodent's core temperature never fall this low.
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See answer in Lehninger on page AS–14.
Last updated: 24 September, 2025.
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