CHEM 352—Biochemistry II—Spring 2025
Lipids
01/13
Chapter 10
Suggested Problems—lipids
Course Introduction
Fatty Acid Oxidation
01/15
Chapter 17
Suggested Problems—fatty-acid-oxidation
β–oxidation film
Fatty Acid Oxidation (continued)
01/17
Chapter 17
Diseases of Fatty Acid Metabolism
01/20
Chapter 17
Lipid Biosynthesis
01/22
Chapter 21
Suggested Problems—lipid-biosynthesis
Lipid Biosynthesis (continued)
01/24
Chapter 21
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End: 18:51
Length: 7:46
Hit-and-run epigenome editing
Biological Membranes
01/27
Chapter 11, p. 385–95
Singer SJ and Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes Science 175 720–31
Suggested Problems—biological-membranes
Membrane Dynamics
01/29
Chapter 11, p. 395–402
Membrane Slides
Membrane Transport
01/31
Chapter 11, p. 402–27
Aschroft FM (2006) From molecule to malady Nature 440 440–7
The Nucleotides
02/03
Chapter 8, p. 281–7
Suggested Problems—nucleotides
Nucleotide Biosynthesis
02/05
Chapter 22, p. 910–20
Nucleotide Degradation
  **final topic in unit I
02/07
Chapter 22, p. 920–5
DNA Structure
02/10
Chapter 8, p. 287–93
Suggested Problems—dna-structure
podcast icon What Rosalind Franklin truly contributed to the discovery of DNA’s structure
DNA Figures
DNA Structure (continued)
02/12
Chapter 8, p. 287–93
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Start: 0:50
End: 10:37
Length: 9:47
Related Article: Designer curvature
Designer curvature
RNA Structure
02/14
Chapter 8, p. 293–7
RNA Figures
Nucleic Acid Chemistry
02/17
Chapter 8, p. 297–308
SantaLucia J (1998) A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics PNAS 95 1460–5
Suggested Problems—dna-thermodynamics
Genomes
02/19
Chapter 24, p. 979–85
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Start: 0:49
End: 12:30
Length: 11:41
Waiting for the Revolution
UCSC Genome Browser
ENSEMBL Genome Browser
NCBI Genome Browser
(m) Local Alignment
02/21
Suggested Problems—local-alignment
BLAST @ NCBI
DNA Packing
02/24
Chapter 24, p. 985–1003
Suggested Problems—dna-packing
DNA Packing Figures
(m) We be GELlin'
02/26
Chapter 3, p. 92–96
Yakhnin AV, Yakhnin H and Babitzke P (2012) Gel mobility shift assays to detect protein-RNA interactions Methods Mol Biol 905201-11
Gygi SP, Corthals GL, Zhang Y, Rochon Y and Aebersold R (2000) Evaluation of two-dimensional get electrophoresis–based proteome analysis technology PNAS 97 9390-5
Leblanc, B and Moss, T (2001). DNase I footprinting. In: Moss, T (eds) DNA-Protein Interactions Methods in Molecular Biology 148 Humana Press
DNA Replication
02/28
Chapter 25, p. 1011–27
Suggested Problems—dna-replication
American Scientists postage stamps, issued 16 June, 2001
DNA Polymerase Figures
No Class—Spring Recess
03/03
 No Class—Spring Recess
03/05
No Class—Spring Recess
03/07
(m) DNA Sequencing
03/10
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Start: 16:44
End: 23:01
Length: 6:16
The future of DNA sequencing
Suggested Problems—dna-sequencing
(m) Polymerase Chain Reaction
03/12
Chapter 9, p. 327–331
(m) Polymerase Chain Reaction (continued)
  **final topic in unit II
03/14
Chapter 9, p. 327–331
Suggested Problems—polymerase-chain-reaction
Primer Blast
DNA Repair
03/17
Chapter 25, p. 1027–38
DNA Recombination
03/19
Chapter 25, p. 1038–52
DNA–Dependent RNA Synthesis
03/21
Chapter 26, p. 1057–69
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Start: 0:54
End: 10:40
Length: 9:46
Related Article: A GPS for Navigating DNA
A GPS for Navigating DNA
RNA Processing
03/24
Chapter 26, p. 1069–85
Suggested Problems—rna-processing
Lecture Audio
Protein Synthesis
03/26
Chapter 27, p. 1103–39
Suggested Problems—protein-synthesis
Protein Synthesis (continued)
03/28
Chapter 27, p. 1103–39
Ribosome Figures
Codon Usage Tool
Protein Targeting and Degradation
03/31
Chapter 27, p. 1139–49
Suggested Problems—protein-degradation
(m) Recombinant Protein Expression
04/02
Recombinant Protein Expression Figures
(m) Absorbance Spectroscopy
04/04
Box 3, p. 80
Suggested Problems—absorbance
Absorbance Figures
(m) Emission Spectroscopy
04/07
Chapter 19, p. 771–6
Box 12–3, p. 448–9
Emission Spectroscopy Slides
(m) Nuclear Magnetic Resonance of Proteins
04/09
Box 4–5, p. 134–6
(m) Nuclear Magnetic Resonance of Proteins (continued)
  **final topic in unit III
04/11
Box 4–5, p. 134–6
Suggested Problems—nuclear-magnetic-resonance
NMR Slides
(m) X-ray Crystallography of Proteins
04/14
Box 4–5, p. 134–6
(m) X-ray Crystallography of Proteins (continued)
04/16
Box 4–5, p. 134–6
X-ray Figures
No Class—Easter Recess
04/18
No Class—Easter Recess
04/21
Protein Folding
04/23
Chapter 4, p. 143–151
(m) Equilibrium Studies of Protein Folding
04/25
Chapter 4, p. 143–151
Suggested Problems—protein-folding
(m) Equilibrium Studies of Protein Folding (continued)
04/28
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End: 13:14
Length: 13:14
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Diseases of Protein Folding
04/30
Reynaud E (2010) Protein misfolding and degenerative diseases Nature Ed 3 28
Urea Denaturation Figures
Student Course Evaluation
Final Exam—8:00
05/02
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